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Now 45, Valor doesn’t have that kind of time. Or money. So he studied neurobiology, taking online classes from Stanford, Vanderbilt, Duke and other universities. Moving his right eye to control his computer, he used social media to build a coalition of other open-science activists who work in amateur labs such as BioCurious, Berkeley Biolabs, and Bio Tech & Beyond. Then he founded SciOpen Research Group, a virtual company for research that relies on crowd-sourced fundraising, global collaborations and shared scientific discoveries, all contrary to the traditional closed private-research model.

The open approach, writes Valor, “allows people with ideas to bootstrap investigations and complete them doing professional-quality research at a tenth of the cost of traditional research institutions, “The failure rate might be high, but the barrier to entry for innovation ballet flats/ black leather flats/ oxford shoes/ monks/ women's flats/ flat leather shoes/ buckle up shoes/ black and white/ is quite low, So it will allow for novel ideas to be tried against problems which have seemed insurmountable — i.e, ‘unprofitable’ — for a long time.”, Data, he says, is not a profit-generating commodity; it is a “shared commons in which ideas can flourish.”..

He continues: “We want to create a situation where anyone with an idea can test or develop that idea in their garage.”. Valor — who can’t walk, speak, eat or even breathe on his own — created the company’s domain, its email and website, set up its infrastructure and submitted regulatory paperwork, relying on his family only to physically help open bank accounts. “Utilizing cloud infrastructure, we can communicate, plan and execute activities just like any other traditional company,” he writes. When specific expertise is needed, “I have a wide and growing network of recognized experts with whom I consult.”.

His SciOpen group’s cloud-based sharing of knowledge challenges the costly brick-and-mortar pharmaceutical industry that must protect its discoveries and its profits, The industry defends its traditional approach, saying it ensures drug safety, efficacy and protection of intellectual property, “Companies have to recoup their investment in such research,” said Jennifer Wall, a spokeswoman for the Pharmaceutical Research and Manufacturers of America, “You can’t discover medicines at a snap of a finger — it takes a long time because of the challenges and complexities involved,” and the failure rate in clinical trials is quite high, she said, The success of patient advocacy groups in the USA has shown that people with diseases “are understandably motivated to put in the effort to learn more about their ballet flats/ black leather flats/ oxford shoes/ monks/ women's flats/ flat leather shoes/ buckle up shoes/ black and white/ conditions,” said Glasgow, Scotland-based Graham Steele of the Open Knowledge Foundation..

In Valor’s bedroom, the tableau seems helpless and coldly clinical. But online, he is adroitly concluding a $30,000 “crowd-funded” campaign to fund a small research project at the La Jolla-based Salk Institute and is writing up findings for publication. “He clearly understands the science behind drug discovery research and the conceptual hang-ups that have prevented big pharmaceutical companies from developing any effective treatment for diseases like ALS, AD and Huntington’s,” said Schubert.

Valor has already outlived the normal three-to-five-year prognosis for ALS patients, and he nurtures long-term dreams, He wants SciOpen Research Group to study the “epigenetics” of ALS, to learn if the environment or aging alters gene expression, He also hopes to fund stem cell research that would watch how neurons respond to stressful or toxic situations, “Everything I had built, bought, saved or enjoyed in my life was taken from me or consumed by this disease,” he says, using his eyes to type an answer to ballet flats/ black leather flats/ oxford shoes/ monks/ women's flats/ flat leather shoes/ buckle up shoes/ black and white/ a question, “I refuse to go away, however.”..

But Eric Valor’s message grows stronger as a progressive disease lays waste to his body while he organizes a new way to develop lifesaving drugs. From his bed in Aptos, his eyes locking in on letters on a computer screen, he taps out a declaration. “I am frustrated by both the pace and method of research,” he writes. The computer suspended above his bed is headquarters for SciOpen Research Group, a nonprofit biotech organization that Valor founded to accelerate research into amyotrophic lateral sclerosis, also known as “Lou Gehrig’s disease,” a rare neurodegenerative disease.

Immobilized, he has become a “biotech guerrilla” who searches ballet flats/ black leather flats/ oxford shoes/ monks/ women's flats/ flat leather shoes/ buckle up shoes/ black and white/ databases for new compounds, fundraises, designs study protocols and sets up research to speed pharmacological innovation, And while the odds are long that one desperately ill man can change a world of research protocols, others are taking note, “His intellect and willingness to contribute to the fight should be an inspiration to all scientists to find a therapy for ALS and all neurodegenerative diseases,” said professor Dave Schubert, director of the Salk Institute’s Cellular Neurobiology Laboratory..

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